Mitral valve prolapse (MVP) is a heart valve condition marked by the displacement of an abnormally thickened mitral valve leaflet into the atria of the heart during systole. In its nonclassic form, MVP carries a low risk of complications. In severe cases of classic MVP, complications include mitral regurgitation, infective endocarditis, and — in rare circumstances — cardiac arrest usually resulting in sudden death. == Overview == The mitral valve, so named because of its resemblance to a bishop's miter, is the heart valve that prevents the backflow of blood from the left Ventricle (heart) into the left atria of the heart. It is composed of two leaflets (one anterior, one posterior) that close when the left ventricle contracts. Each leaflet is composed of three layers of biological_tissue: the ''atrialis'', ''fibrosa'', and ''spongiosa''. Patients with classic mitral valve prolapse have excess connective tissue that thickens the spongiosa and separates collagen bundles in the fibrosa. This weakens the leaflets and adjacent tissue, resulting in increased leaflet area and elongation of the chordae tendineae. Elongation of the chordae often causes rupture, and is commonly found in the chordae tendineae attached to the posterior leaflet. Advanced lesions — also commonly involving the posterior leaflet — lead to leaflet folding, inversion, and displacement toward the left atrium. == History == For many years, mitral valve prolapse was a poorly understood anomaly associated with a wide variety of both related and seemingly unrelated signs and symptoms, including late systole heart murmur, inexplicable panic attacks, and polythelia (extra nipples). Recent studies suggest that these symptoms were incorrectly linked to MVP because the disorder was simply over-diagnosed at the time. Continuously-evolving criteria for diagnosis of MVP with echocardiography made proper diagnosis difficult, and hence many subjects without MVP were included in studies of the disorder and its prevalence. In fact, some modern studies report that as many as 55% of the population would be diagnosed with MVP if older, less reliable methods of MVP diagnosis — notably M-mode echocardiography — were used today. In recent years, new criteria have been proposed as an objective measure for diagnosis of MVP using more reliable two- and three-dimensional echocardiography. The disorder has also been classified into a number of subtypes with respect to these criteria. == Subtypes == echocardiography_techniques_which_can_pinpoint_abnormal_leaflet_thickening_and_other_related_pathology.">Image:MVP_subtypes.png|framed|378px|Diagnosis of mitral valve prolapse is based on modern echocardiography techniques which can pinpoint abnormal leaflet thickening and other related pathology. Prolapsed mitral valves are classified into several subtypes, based on leaflet thickness, concavity, and type of connection to the mitral annulus. Subtypes can be described as classic, nonclassic, symmetric, asymmetric, flail, or non-flail. === Classic vs. nonclassic === Prolapse occurs when the mitral valve leaflets are displaced more than 2 mm above the mitral annulus high points. The condition can be further divided into classic and nonclassic subtypes based on the thickness of the mitral valve leaflets: up to 5 mm is considered nonclassic, while anything beyond 5 mm is considered classic MVP. === Symmetric vs. asymmetric === Classical prolapse may be subdivided into symmetric and asymmetric, referring to the point at which leaflet tips join the mitral annulus. In symmetric coaptation, leaflet tips meet at a common point on the annulus. Asymmetric coaptation is marked by one leaflet displaced toward the atrium with respect to the other. Patients with asymmetric prolapse are prone to severe deterioration of the mitral valve, with the possible rupture of the chordae tendineae and the development of a flail leaflet. === Flail vs. non-flail === Asymmetric prolapse is further subdivided into flail and non-flail. Flail prolapse occurs when a leaflet tip turns outward, becoming concave toward the left atrium, causing the deterioration of the mitral valve. The severity of flail leaflet varies, ranging from tip eversion to chordal rupture. Dissociation of leaflet and chordae tendineae provides for unrestricted motion of the leaflet (hence "flail leaflet"). Thus patients with flail leaflets have a higher prevalence of mitral regurgitation than those with the non-flail subtype. == Signs and symptoms == Some patients with MVP experience heart palpitations, atrial fibrillation, or fainting, though the prevalence of these symptoms does not differ significantly from the general population. Between 11 and 15 percent of patients experience moderate chest pain and shortness of breath. These symptoms are most likely not caused directly by the prolapsing mitral valve, but rather by the mitral regurgitation that often results from prolapse. For unknown reasons, MVP patients tend to have a low body mass index (BMI) and are typically leaner than individuals without MVP. ===Auscultation=== Upon auscultation of an individual with mitral valve prolapse, a mid-systolic click, followed by a late systolic heart sounds heard best at the apex is common. == Complications == === Mitral regurgitation === Most cases of mitral valve prolapse are associated with mild mitral regurgitation, where blood aberrantly flows from the left ventricle into the left atrium during systole. Approximately 7% of classic MVP patients experience severe regurgitation, often due to chordae tendineae rupture. === Sudden death === Severe mitral valve prolapse is associated with arrhythmias and atrial fibrillation that may progress and lead to cardiac arrest. As there is no evidence that a prolapsed valve itself contributes to such arrythmias, these complications are more likely due to mitral regurgitation and congestive heart failure. == Prognosis == The major predictors of mortality are the severity of mitral regurgitation and the ejection fraction. Patients with moderate to severe mitral regurgitation have a relative risk for mortality that is three times that of the general population. Similarly, a left ventricular ejection fraction at or below 50% carries a relative risk of 3.8. ==Diagnosis== {| width="500" cellspacing="0" border="1" align="right" style="border-collapse: collapse; margin-left:10px" |- bgcolor="#cccccc" | align="center" | | align="center" | |- | colspan=2 style="padding:3px" | ''Transthoracic and transesophageal echocardiograms of mitral valve prolapse''
''Left''. A transthoracic echocardiogram displaying prolapse of both the anterior leaflet (AL) and posterior leaflet (PL) of the mitral valve. ''Right''. A transesophageal echocardiogram displaying the heart in the same individual as in the figure to the left. Both figures are during ventricular systole, with the mitral valve closed. AL=Anterior leaflet; PL=Posterior leaflet; LA=Left atrium; LV=Left ventricle; AO=Aorta; Blue line represents the plane of the mitral valve annulus. |} Echocardiography, a noninvasive method of visualizing the heart, is the most useful method of diagnosing a prolapsed mitral valve. Two- and three-dimensional echocardiography are particularly valuable as they allow visualization of the mitral leaflets relative to the mitral annulus. This allows measurement of the leaflet thickness and their displacement relative to the annulus. Thickening of the mitral leaflets above 2 mm indicates mitral valve prolapse. == Treatment == Mitral valve prolapse can be treated with mitral valve replacement of the mitral valve. This may be necessary in as many as 11% of patients with classic MVP, and is indicated for patients with and ejection fraction below 60% and progressive left ventricular dysfunction. == Prevalence == Figures vary widely, but most recent studies of mitral valve prolapse indicate a prevalence of 1.3% for classic and 1.1% for nonclassic MVP. MVP occurs less frequently in children, and does not vary significantly with sex. Though the reasons are not understood, patients with mitral valve prolapse tend to be leaner with a relatively low body mass index. == References == * [http://www.medreviews.com/pdfs/articles/RICM_22_73.pdf Mitral Valve Prolapse - Time For A Fresh Look] * [http://content.nejm.org/cgi/content/full/341/1/1 Prevalence and Clinical Outcome of Mitral-Valve Prolapse] * [http://circ.ahajournals.org/cgi/content/full/106/11/1305 Mitral Valve Prolapse Prevalence and Complications] * [http://www.nlm.nih.gov/medlineplus/ency/article/000180.htm MedlinePlus Medical Encyclopedia: Mitral Valve Prolapse] == External links == * [http://www.tmc.edu/thi/mvp.html Mitral Valve Prolapse - Texas Heart Institute Information Center] * [http://www.consciouschoice.com/holisticmd/hmd093.html Mitral Valve Prolapse - Conscious Choice] Valvular heart disease
As per the review article I just added to the references section of this article, a lot of the information in this article is incorrect. Not the fault of the authors -- Mitral valve prolapse was an over-diagnosed entity that a lot of symptoms were related to, that haven't held up under closer scrutiny. User:Ksheka 02:30, Apr 23, 2004 (UTC) :Duly noted. I've rewritten this article from scratch with the provided review article as a foundation. Your comments are always welcome! --User:Diberri | User talk:Diberri 19:30, May 18, 2004 (UTC)
See other meanings of words starting from letter:
Words begining with Mitral_valve_prolapse:
Mitral_valve_prolapse
Mitral_valve_prolapse
Mitral valve prolapse
Mitral valve prolapse (MVP) is a heart valve condition marked by the displacement of an abnormally thickened mitral valve leaflet into the atria of the heart during systole. In its nonclassic form, MVP carries a low risk of complications. In severe cases of classic MVP, complications include mitral regurgitation, infective endocarditis, and — in rare circumstances — cardiac arrest usually resulting in sudden death. == Overview == The mitral valve, so named because of its resemblance to a bishop's miter, is the heart valve that prevents the backflow of blood from the left Ventricle (heart) into the left atria of the heart. It is composed of two leaflets (one anterior, one posterior) that close when the left ventricle contracts. Each leaflet is composed of three layers of biological_tissue: the ''atrialis'', ''fibrosa'', and ''spongiosa''. Patients with classic mitral valve prolapse have excess connective tissue that thickens the spongiosa and separates collagen bundles in the fibrosa. This weakens the leaflets and adjacent tissue, resulting in increased leaflet area and elongation of the chordae tendineae. Elongation of the chordae often causes rupture, and is commonly found in the chordae tendineae attached to the posterior leaflet. Advanced lesions — also commonly involving the posterior leaflet — lead to leaflet folding, inversion, and displacement toward the left atrium. == History == For many years, mitral valve prolapse was a poorly understood anomaly associated with a wide variety of both related and seemingly unrelated signs and symptoms, including late systole heart murmur, inexplicable panic attacks, and polythelia (extra nipples). Recent studies suggest that these symptoms were incorrectly linked to MVP because the disorder was simply over-diagnosed at the time. Continuously-evolving criteria for diagnosis of MVP with echocardiography made proper diagnosis difficult, and hence many subjects without MVP were included in studies of the disorder and its prevalence. In fact, some modern studies report that as many as 55% of the population would be diagnosed with MVP if older, less reliable methods of MVP diagnosis — notably M-mode echocardiography — were used today. In recent years, new criteria have been proposed as an objective measure for diagnosis of MVP using more reliable two- and three-dimensional echocardiography. The disorder has also been classified into a number of subtypes with respect to these criteria. == Subtypes == echocardiography_techniques_which_can_pinpoint_abnormal_leaflet_thickening_and_other_related_pathology.">Image:MVP_subtypes.png|framed|378px|Diagnosis of mitral valve prolapse is based on modern echocardiography techniques which can pinpoint abnormal leaflet thickening and other related pathology. Prolapsed mitral valves are classified into several subtypes, based on leaflet thickness, concavity, and type of connection to the mitral annulus. Subtypes can be described as classic, nonclassic, symmetric, asymmetric, flail, or non-flail. === Classic vs. nonclassic === Prolapse occurs when the mitral valve leaflets are displaced more than 2 mm above the mitral annulus high points. The condition can be further divided into classic and nonclassic subtypes based on the thickness of the mitral valve leaflets: up to 5 mm is considered nonclassic, while anything beyond 5 mm is considered classic MVP. === Symmetric vs. asymmetric === Classical prolapse may be subdivided into symmetric and asymmetric, referring to the point at which leaflet tips join the mitral annulus. In symmetric coaptation, leaflet tips meet at a common point on the annulus. Asymmetric coaptation is marked by one leaflet displaced toward the atrium with respect to the other. Patients with asymmetric prolapse are prone to severe deterioration of the mitral valve, with the possible rupture of the chordae tendineae and the development of a flail leaflet. === Flail vs. non-flail === Asymmetric prolapse is further subdivided into flail and non-flail. Flail prolapse occurs when a leaflet tip turns outward, becoming concave toward the left atrium, causing the deterioration of the mitral valve. The severity of flail leaflet varies, ranging from tip eversion to chordal rupture. Dissociation of leaflet and chordae tendineae provides for unrestricted motion of the leaflet (hence "flail leaflet"). Thus patients with flail leaflets have a higher prevalence of mitral regurgitation than those with the non-flail subtype. == Signs and symptoms == Some patients with MVP experience heart palpitations, atrial fibrillation, or fainting, though the prevalence of these symptoms does not differ significantly from the general population. Between 11 and 15 percent of patients experience moderate chest pain and shortness of breath. These symptoms are most likely not caused directly by the prolapsing mitral valve, but rather by the mitral regurgitation that often results from prolapse. For unknown reasons, MVP patients tend to have a low body mass index (BMI) and are typically leaner than individuals without MVP. ===Auscultation=== Upon auscultation of an individual with mitral valve prolapse, a mid-systolic click, followed by a late systolic heart sounds heard best at the apex is common. == Complications == === Mitral regurgitation === Most cases of mitral valve prolapse are associated with mild mitral regurgitation, where blood aberrantly flows from the left ventricle into the left atrium during systole. Approximately 7% of classic MVP patients experience severe regurgitation, often due to chordae tendineae rupture. === Sudden death === Severe mitral valve prolapse is associated with arrhythmias and atrial fibrillation that may progress and lead to cardiac arrest. As there is no evidence that a prolapsed valve itself contributes to such arrythmias, these complications are more likely due to mitral regurgitation and congestive heart failure. == Prognosis == The major predictors of mortality are the severity of mitral regurgitation and the ejection fraction. Patients with moderate to severe mitral regurgitation have a relative risk for mortality that is three times that of the general population. Similarly, a left ventricular ejection fraction at or below 50% carries a relative risk of 3.8. ==Diagnosis== {| width="500" cellspacing="0" border="1" align="right" style="border-collapse: collapse; margin-left:10px" |- bgcolor="#cccccc" | align="center" | | align="center" | |- | colspan=2 style="padding:3px" | ''Transthoracic and transesophageal echocardiograms of mitral valve prolapse''
''Left''. A transthoracic echocardiogram displaying prolapse of both the anterior leaflet (AL) and posterior leaflet (PL) of the mitral valve. ''Right''. A transesophageal echocardiogram displaying the heart in the same individual as in the figure to the left. Both figures are during ventricular systole, with the mitral valve closed. AL=Anterior leaflet; PL=Posterior leaflet; LA=Left atrium; LV=Left ventricle; AO=Aorta; Blue line represents the plane of the mitral valve annulus. |} Echocardiography, a noninvasive method of visualizing the heart, is the most useful method of diagnosing a prolapsed mitral valve. Two- and three-dimensional echocardiography are particularly valuable as they allow visualization of the mitral leaflets relative to the mitral annulus. This allows measurement of the leaflet thickness and their displacement relative to the annulus. Thickening of the mitral leaflets above 2 mm indicates mitral valve prolapse. == Treatment == Mitral valve prolapse can be treated with mitral valve replacement of the mitral valve. This may be necessary in as many as 11% of patients with classic MVP, and is indicated for patients with and ejection fraction below 60% and progressive left ventricular dysfunction. == Prevalence == Figures vary widely, but most recent studies of mitral valve prolapse indicate a prevalence of 1.3% for classic and 1.1% for nonclassic MVP. MVP occurs less frequently in children, and does not vary significantly with sex. Though the reasons are not understood, patients with mitral valve prolapse tend to be leaner with a relatively low body mass index. == References == * [http://www.medreviews.com/pdfs/articles/RICM_22_73.pdf Mitral Valve Prolapse - Time For A Fresh Look] * [http://content.nejm.org/cgi/content/full/341/1/1 Prevalence and Clinical Outcome of Mitral-Valve Prolapse] * [http://circ.ahajournals.org/cgi/content/full/106/11/1305 Mitral Valve Prolapse Prevalence and Complications] * [http://www.nlm.nih.gov/medlineplus/ency/article/000180.htm MedlinePlus Medical Encyclopedia: Mitral Valve Prolapse] == External links == * [http://www.tmc.edu/thi/mvp.html Mitral Valve Prolapse - Texas Heart Institute Information Center] * [http://www.consciouschoice.com/holisticmd/hmd093.html Mitral Valve Prolapse - Conscious Choice] Valvular heart disease
Mitral valve prolapse
As per the review article I just added to the references section of this article, a lot of the information in this article is incorrect. Not the fault of the authors -- Mitral valve prolapse was an over-diagnosed entity that a lot of symptoms were related to, that haven't held up under closer scrutiny. User:Ksheka 02:30, Apr 23, 2004 (UTC) :Duly noted. I've rewritten this article from scratch with the provided review article as a foundation. Your comments are always welcome! --User:Diberri | User talk:Diberri 19:30, May 18, 2004 (UTC)
See other meanings of words starting from letter:
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