A deoxyribonuclease (DNase, for short) is any enzyme that catalyzes the hydrolysis of phosphodiester bonds in the DNA backbone. Deoxyribonucleases are thus one type of nuclease. A wide variety of deoxyribonucleases are known, which differ in their substrate (biochemistry) specificities, chemical mechanisms, and biological functions. Some DNases cleave only residues at the ends of DNA molecules (exodeoxyribonucleases, a type of exonuclease). Others cleave anywhere along the chain (endodeoxyribonucleases, a subset of endonucleases). Some are fairly indiscriminate about the DNA sequence at which they cut, while others, including restriction enzymes, are very sequence-specific. Some cleave only double-stranded DNA, others are specific for single-stranded molecules, and still others are active toward both. Deoxyribonuclease I cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. Deoxyribonuclease II, or Acid DNase, hydrolyzes deoxyribonucleotide linkages in native and denatured DNA yielding products with 3'-phosphates. As the name implies, it is more effective at acid pHs. There are several known DNases II, including DNase II alpha (usually just called DNase II) and DNase II beta (also called DLAD, or DNase II-Like Acid DNase). EC 3.1.21
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Words begining with Deoxyribonuclease:
Deoxyribonuclease
Deoxyribonuclease
A deoxyribonuclease (DNase, for short) is any enzyme that catalyzes the hydrolysis of phosphodiester bonds in the DNA backbone. Deoxyribonucleases are thus one type of nuclease. A wide variety of deoxyribonucleases are known, which differ in their substrate (biochemistry) specificities, chemical mechanisms, and biological functions. Some DNases cleave only residues at the ends of DNA molecules (exodeoxyribonucleases, a type of exonuclease). Others cleave anywhere along the chain (endodeoxyribonucleases, a subset of endonucleases). Some are fairly indiscriminate about the DNA sequence at which they cut, while others, including restriction enzymes, are very sequence-specific. Some cleave only double-stranded DNA, others are specific for single-stranded molecules, and still others are active toward both. Deoxyribonuclease I cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. Deoxyribonuclease II, or Acid DNase, hydrolyzes deoxyribonucleotide linkages in native and denatured DNA yielding products with 3'-phosphates. As the name implies, it is more effective at acid pHs. There are several known DNases II, including DNase II alpha (usually just called DNase II) and DNase II beta (also called DLAD, or DNase II-Like Acid DNase). EC 3.1.21
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DA | DB | DC | DE | DF | DG | DH | DI | DJ | DK | DL | DM | DN | DO | DP | DR | DS | DT | DU | DW | DX | DY | DZ |Words begining with Deoxyribonuclease:
Deoxyribonuclease
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