The dentate gyrus is part of the hippocampal formation. It serves as the primary afferent area to the hippocampus. It contains granule cell, which project to the pyramidal cell of layers CA2-4 of the hippocampus. The granule cell, principal excitatory neurons in the dentate gyrus, receive inputs from areas in the neocortex. Most of these inputs are provided by the perforant pathway, the axons of spiny stellate cells at the entorhinal cortex. The perforant pathway is divided in the medial perforant path and the lateral perforant path generated respectively at the medial and lateral portions of the entorhinal cortex. The medial perforant path synapses onto the proximal dendritic area of the granule cell, while the lateral perforant path does it onto the distal dendrites of these same cells. The dentate gyrus is also one of the few regions of the brain where neurogenesis takes place. Neurogenesis is thought to play a role in the formation of new memory. It has also been found to be increased in response to both antidepressant and exercise. This implies that neurogenesis may improve symptoms of Clinical depression. Cerebrum
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Dentate gyrus
The dentate gyrus is part of the hippocampal formation. It serves as the primary afferent area to the hippocampus. It contains granule cell, which project to the pyramidal cell of layers CA2-4 of the hippocampus. The granule cell, principal excitatory neurons in the dentate gyrus, receive inputs from areas in the neocortex. Most of these inputs are provided by the perforant pathway, the axons of spiny stellate cells at the entorhinal cortex. The perforant pathway is divided in the medial perforant path and the lateral perforant path generated respectively at the medial and lateral portions of the entorhinal cortex. The medial perforant path synapses onto the proximal dendritic area of the granule cell, while the lateral perforant path does it onto the distal dendrites of these same cells. The dentate gyrus is also one of the few regions of the brain where neurogenesis takes place. Neurogenesis is thought to play a role in the formation of new memory. It has also been found to be increased in response to both antidepressant and exercise. This implies that neurogenesis may improve symptoms of Clinical depression. Cerebrum
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