
A cyanide is any chemical compound that contains the group C≡N, with the carbon atom chemical bond to the nitrogen atom. inorganic chemistry cyanides contain the highly toxic cyanide ion carbonnitrogen- and are the salts of the acid hydrogen cyanide (hydrogenCN). Organic chemistry cyanides contain the cyano group (CN) single-bonded to another carbon atom are also known as nitriles. Two cyanide ions can bond to each other via their carbon atoms, forming the gas cyanogen (NC-CN). == Appearance == Hydrogen cyanide is a colorless gas with a faint, bitter, almond-like odor. Some people are unable to smell cyanide at all, due to a genetic trait. Sodium cyanide (NaCN) and potassium cyanide (KCN) are both white solids or powder with a bitter, almond-like odor in damp air. == Occurrence and use == Cyanides can be produced by certain bacterium, fungi, and algae, and are found in a number of foods and plants. Cyanide occurs naturally in cassava roots (aka manioc), which are potato-like tubers of cassava plants grown in tropical countries; these must be processed prior to consumption (usually by extended boiling). Fruits which have a pit, such as cherry or apricots, often contain either cyanides or cyanogenic glycosides in the pit. Bitter almonds, from which almond oil and flavoring is made, also contain cyanide. Hydrogen cyanide is contained in vehicle exhaust and in tobacco smoke. The smoke of burning plastics contains hydrogen cyanide, and house fires often result in cyanide poisonings. A deep blue pigment called Prussian blue, used in the making of blueprints, is iron (III) ferrocyanide. (Hence the name ''cyanide'', from cyan, a shade of blue.) It produces hydrogen cyanide when exposed to acids. Cyanides are one of the very few soluble compounds of gold, and thus are used in electroplating, gold mining, metallurgy and jewellery for chemical gilding, buffing, and extraction of gold. Cyanides and hydrogen cyanide are used in production of chemicals, photographic development, making plastics, fumigating ships, and some mining processes. Potassium Ferrocyanide is used to achieve a blue colour on cast bronze sculptures during the final finishing stage of the sculpture. On its own it will produce a very dark shade of blue and is often mixed with other chemicals to achieve the desired tint and hue. It is applied using a torch and paint brush while wearing the standard safety equipment used for any patina application; rubber gloves, safety glasses and a respirator. The actual amount of cyanide in the mixture varies according to the recipes used by each foundry. == Effects on the human body == To deal with the cyanides contained in many foods, the body has an enzyme (rhodanide synthetase) which can convert small amounts of cyanides to the harmless sulfur-containing thiocyanate (sulfurCN−). The cyanide ion is also a component of vitamin B12, where it is one of the ligands for the cobalt ion. In larger amounts, cyanides are harmful. Symptoms of moderate poisoning include vomiting, convulsions, deep breathing, shortness of breath and anxiety; more serious cases result in convulsions, loss of consciousness, and death after apnea and cardiac arrest due to hypoxemia. The lethal dose for adults is 200–300 mg of potassium or sodium cyanide, or 50 mg of hydrogen cyanide. Exposure to lower levels of cyanide over a long period (e.g. after use of cassava roots as a primary food source in tropical Africa) results in increased blood cyanide levels. These may result in weakness of the fingers and toes, difficulty walking, dimness of vision, deafness, and decreased thyroid gland function, but chemicals other than cyanide may contribute to these effects. Skin contact with cyanide can produce irritation and sores. It is not known whether cyanides can directly cause birth defects in people. Birth defects were seen in rats that ate diets of cassava roots. Effects on the reproductive system were seen in rats and mice that drank water containing sodium cyanide. There are medical tests to measure blood and urine levels of cyanide; however, small amounts of cyanide are not always detectable in blood and urine. Tissue levels of cyanide can be measured if cyanide poisoning is suspected, but cyanide is rapidly cleared from the body, so the tests must be done soon after the exposure. An almond-like odor in the breath may alert a doctor that a person was exposed to cyanide. ==Mechanism of toxicity and treatment== The cyanide ion kills all aerobic organisms by shutting down the respiration in cells. It interrupts the Electron transfer chain in the inner membrane of the mitochondrion because it binds more strongly than oxygen to the iron3+ in Cytochrome c oxidase3, preventing this cytochrome from combining electrons with oxygen. Contrary to popular belief, cyanide does not bind well to ferrous hemoproteins, such as hemoglobin, the mechanism which makes carbon monoxide toxic. One of the therapies for cyanide poisoning is to convert part of the hemoglobin of the blood from ferrous hemoglobin to ferric; this creates a pool of binding potential that can divert cyanide from the cytochromes it poisons. This is done with the compound 4-Dimethylaminophenyl, or with sodium nitrite. The standard cyanide antidote kit uses a small inhaled dose of amyl nitrite followed by intravenous sodium nitrite. This converts a portion of the hemoglobin's iron from ferrous iron to ferric iron, converting the hemoglobin into methemoglobin. Cyanide is more strongly drawn to methemoglobin than to the cytochrome oxidase of the cells, effectively pulling the cyanide off the cells and onto the methemoglobin. Once bound with the cyanide, the methemoglobin becomes cyanmethemoglobin. The next part of the cyanide antidote kit is sodium thiosulfate, which is administered intravenously. The sodium thiosulfate and cyanmethemoglobin becomes thiocyanate, releasing the hemoglobin, and the thiocyanate is excreted by the kidneys. ==Use as a poison== The cyanide ion, if used as poison, is generally delivered in the form of gaseous hydrogen cyanide or in the form of potassium cyanide (KCN) or sodium cyanide (NaCN). Zyklon B, the poison gas used in Nazi Germany gas chambers during the Holocaust, works by delivering hydrogen cyanide gas. Cyanide is also the compound used in United States death penalty chambers. Cyanide salts are sometimes used as fast acting "suicide pills". When they reach the stomach acids, cyanide ions are released; therefore they work faster on an empty stomach. Famous cyanide salt suicides include: *Hermann Göring *Joseph Goebbels *Adolf Hitler (debatable, see article on Hitler's death) *Alan Turing *Martin Bormann (dubious) *Heinrich Himmler *Erwin Rommel *Odilo Globocnik *Peoples Temple Jonestown mass suicide Poisoning by cyanide also figures prominently in crime fiction, for example Agatha Christie's ''Sparkling Cyanide'' (also titled ''Remembered Death''); cyanide is the instrument of one murder in ''The Big Sleep'' by Raymond Chandler. See also: Victims of poisoning Cyanides were stockpiled in both the Soviet Union and the United States chemical weapons arsenals in the 1950s and 1960s. During the Cold War, the Soviet Union was thought to be planning to use hydrogen cyanide as a "blitzkrieg" weapon to clear a path through the opposing front line, knowing that the harmful gas itself would evaporate and allow unprotected access to the captured zone. Some spy agents also carried glasses with cyanide in the frames. If they were caught by the enemy, they could casually chew the frame, releasing the cyanide, and die before being tortured or getting information extracted from them. The "cyanide glasses" can be found in the Washington D.C Spy Museum. == Mining == Cyanide salts are used in silver and gold mining, called the ''cyanide process''. The high grade ore is finely ground and mixed the cyanide solution (concentration of about two kilogram NaCN per tonne (1000 kilograms) or low grade ores are stacked into heaps and sprayed with cyanide solution (concentration of about one kilogram NaCN per tonne (1000 kilograms). The precious metal cations bind to the cyanide anions and form a ''soluble'' cyanide. The pregnant liquor is separated from the left-over dirt which is discarded to a tailing pond or spent (the recoverable gold having been removed) heap. The metal is recovered from the pregnant solution with zincdust that replace the gold in solution or by adsorption onto activated carbon. This process can result in environmental and health problems. Cyanide is highly reactive it decomposes rapidly in sunlight. It can mobilize some heavy metals like mercury (if mercury is present). Gold can also be associated with arsenopyrite, a pyrite (fools gold) where some iron gets replaced with arsenic. == Fishing == Cyanides are used to capture live fish near coral reefs for the aquarium and seafood market. This illegal fishing occurs mainly in the Philippines, Indonesia and the Caribbean to supply the 2 million marine aquarium owners in the world(Christie). In this method, a diver uses a large, needleless syringe to squirt a cyanide solution into areas where the fish are hiding, stunning them so that they can be easily gathered. The cyanide stuns the fish by affecting the uptake of Oxygen in their gills (Christie 2). Environmental organizations decry the practice, as do responsible aquarists and aquarium dealers. To prevent the trade of illegally caught aquarium fish, the Marine Aquarium Council have created a certification in which the tropical fish are caught legally with nets only. To insure authenticity, "MAC Certified marine organisms bear the 'MAC Certified' label on the tanks and boxes in which they are kept and shipped." *http://www.aquariumcouncil.org/subpage.asp?section=13 MAC Certification. The MAC certified fish are usually healthier and longer lived than cyanide caught fish, since their vital organs are not affeted by the deadly poison. Many fish caught in this fashion die either immediately or in shipping. Those that survive to find their way into pet stores often die from shock, or from massive digestive damage. The high concentrations of cyanide on reefs so harvested has also resulted in cases of cyanide poisioning among local fishermen and their families. The local villages in the Philippines and Indonesia despise the practice of cyanide fishing since they have realized the damaging affects of this poison on fish and reefs (Lowe). Cyanides Toxicology Chemical weapons lv:Cianīdi ==References== * Prof. Patrick Christie, University of Washington, Lecture, 4 May, 2005. * Prof. Patrick Christie, University of Washington, Lecture, 10 May, 2005. * Prof. Celia Lowe, University of Washington, Lecture, 6 May, 2005. == External Links == * [http://www.inchem.org/documents/cicads/cicads/cicad61.htm CICAD 61: Hydrogen cyanide and cyanides] * [http://www.inchem.org/documents/antidote/antidote/ant02.htm#SubSectionNumber:1.13.1 IPCS/CEC Evaluation of antidotes for poisoning by cyanides] * [http://www.atsdr.cdc.gov/MHMI/mmg8.html ATSDR medical management guidelines for cyanide poisoning (US)] * [http://www.hse.gov.uk/pubns/misc076.htm HSE recommendations for first aid treatment of cyanide poisoning (UK)] * [http://agmed.sante.gouv.fr/htm/10/piratox/piratox4.pdf Fiche piratox de prise en charge thérapeutique (France)] (''in French'') * [http://www.aquariumcouncil.org/default.asp Marine Aquarium Council Home Page]
I'm going to put this in talk so people can understand this clearly. I worked on heme proteins (and for that matter cyanide) well over ten years in graduate school and through a couple postdocs. Cyanide is a deadly compound because of its effects on ferric heme proteins. It doesn't bind especially well to ferrous heme proteins (that's carbon monoxide that does so). Cutting off cytochrome c oxidase, which cyanide does very well, will shut off aerobic metabolism, and because of the rise in concentration of metabolic intermediates, eventually shut down all anaerobic metabolism as well. Hemoglobin is a ferrous heme protein. One therapy for cyanide poisoning is to convert part of the hemoglobin in the blood to the ferric form, to provide a pool for internal cyanide and dilute the poison. That therapy would be useless if cyanide preferentially bound to the ferrous form of hemoproteins.User:dwmyers ---- I'm not really stalking you, Bryan. Two queries. (1) I didn't really understand the vitamin B13 sentence-can this be clarified. the second (2) I thought, possibly incorrectly, that almond oil was extrcated from sweet almonds? User:Jimfbleak 06:59 6 Jun 2003 (UTC) == How fast can cyanide kill? == Cyanide's toxicity is well-known. I'm under the impression that a large amount of the stuff is enough to deaden an adult person in seconds. It seems rather weird, though, so is it true? One imagines the suicide pills mentioned in the article would have to be pretty quick. -- User:Kizor 23:38, 9 Feb 2005 (UTC) *Seconds is a bit of an exageration for mortality. A few minutes seems the consensus, although loss of consciousness would be quicker and maybe as little as 30 seconds for a lethal dose of hydrogen cyanide gas. User:Physchim62 09:32, 3 Jun 2005 (UTC) == LD100 == What is the LD-100 (lethal dose at which point 100% of the subjects die) of (pure) cyanide? P.S. is [https://www1.fishersci.com/Coupon?gid=218110&cid=1336 this link] just CN? How can one have just CN? I thought CN was an ion... *LD100 values do not have much meaning as there is always variability in the reaction of individauls to different poisons: this is notoriously true of cyanides. Quoted LD50 values for potassium cyanide are 5–10 mg/kg for rodents. The IDLH (Immediate Danger to Life and Health) value is 25 mg/m3 (measured as cyanide, ''source'' [http://www.cdc.gov/niosh/npg/npgd0522.html NIOSH (US)]). User:Physchim62 10:54, 3 Jun 2005 (UTC) * The "Cyanide standard solution" that you cite will of course contain a counter-ion to ensure its electrical neutrality, doubtless either sodium or potassium. User:Physchim62 10:54, 3 Jun 2005 (UTC) == Antidote == The article does not mention about amyl nitrate being the antidote. Does anyone have any information regarding how soon after exposure to cyanide that amyl nitrate would be affective? Thank you *Amyl nitrite is not strictly an antidote. It is used as first aid, as it can be given my non-medically qualified people, while waiting for a doctor to arrive and administer an intravenous antidote. As amyl nitrite is inhaled, it would only be effective while the victim is still breathing, say during the first five minutes after acute poisoning (in any case, as soon as possible). Having said that, there is some debate as to whether amyl nitrate is effective at all (see the HSE link on the article page). User:Physchim62 09:29, 3 Jun 2005 (UTC)
See other meanings of words starting from letter:
Words begining with Cyanide:
Cyanide
Cyanide
Cyanides
Cyanides
Cyanide_process
Cyanide_process
Cyanide_suicides
Cyanide
A cyanide is any chemical compound that contains the group C≡N, with the carbon atom chemical bond to the nitrogen atom. inorganic chemistry cyanides contain the highly toxic cyanide ion carbonnitrogen- and are the salts of the acid hydrogen cyanide (hydrogenCN). Organic chemistry cyanides contain the cyano group (CN) single-bonded to another carbon atom are also known as nitriles. Two cyanide ions can bond to each other via their carbon atoms, forming the gas cyanogen (NC-CN). == Appearance == Hydrogen cyanide is a colorless gas with a faint, bitter, almond-like odor. Some people are unable to smell cyanide at all, due to a genetic trait. Sodium cyanide (NaCN) and potassium cyanide (KCN) are both white solids or powder with a bitter, almond-like odor in damp air. == Occurrence and use == Cyanides can be produced by certain bacterium, fungi, and algae, and are found in a number of foods and plants. Cyanide occurs naturally in cassava roots (aka manioc), which are potato-like tubers of cassava plants grown in tropical countries; these must be processed prior to consumption (usually by extended boiling). Fruits which have a pit, such as cherry or apricots, often contain either cyanides or cyanogenic glycosides in the pit. Bitter almonds, from which almond oil and flavoring is made, also contain cyanide. Hydrogen cyanide is contained in vehicle exhaust and in tobacco smoke. The smoke of burning plastics contains hydrogen cyanide, and house fires often result in cyanide poisonings. A deep blue pigment called Prussian blue, used in the making of blueprints, is iron (III) ferrocyanide. (Hence the name ''cyanide'', from cyan, a shade of blue.) It produces hydrogen cyanide when exposed to acids. Cyanides are one of the very few soluble compounds of gold, and thus are used in electroplating, gold mining, metallurgy and jewellery for chemical gilding, buffing, and extraction of gold. Cyanides and hydrogen cyanide are used in production of chemicals, photographic development, making plastics, fumigating ships, and some mining processes. Potassium Ferrocyanide is used to achieve a blue colour on cast bronze sculptures during the final finishing stage of the sculpture. On its own it will produce a very dark shade of blue and is often mixed with other chemicals to achieve the desired tint and hue. It is applied using a torch and paint brush while wearing the standard safety equipment used for any patina application; rubber gloves, safety glasses and a respirator. The actual amount of cyanide in the mixture varies according to the recipes used by each foundry. == Effects on the human body == To deal with the cyanides contained in many foods, the body has an enzyme (rhodanide synthetase) which can convert small amounts of cyanides to the harmless sulfur-containing thiocyanate (sulfurCN−). The cyanide ion is also a component of vitamin B12, where it is one of the ligands for the cobalt ion. In larger amounts, cyanides are harmful. Symptoms of moderate poisoning include vomiting, convulsions, deep breathing, shortness of breath and anxiety; more serious cases result in convulsions, loss of consciousness, and death after apnea and cardiac arrest due to hypoxemia. The lethal dose for adults is 200–300 mg of potassium or sodium cyanide, or 50 mg of hydrogen cyanide. Exposure to lower levels of cyanide over a long period (e.g. after use of cassava roots as a primary food source in tropical Africa) results in increased blood cyanide levels. These may result in weakness of the fingers and toes, difficulty walking, dimness of vision, deafness, and decreased thyroid gland function, but chemicals other than cyanide may contribute to these effects. Skin contact with cyanide can produce irritation and sores. It is not known whether cyanides can directly cause birth defects in people. Birth defects were seen in rats that ate diets of cassava roots. Effects on the reproductive system were seen in rats and mice that drank water containing sodium cyanide. There are medical tests to measure blood and urine levels of cyanide; however, small amounts of cyanide are not always detectable in blood and urine. Tissue levels of cyanide can be measured if cyanide poisoning is suspected, but cyanide is rapidly cleared from the body, so the tests must be done soon after the exposure. An almond-like odor in the breath may alert a doctor that a person was exposed to cyanide. ==Mechanism of toxicity and treatment== The cyanide ion kills all aerobic organisms by shutting down the respiration in cells. It interrupts the Electron transfer chain in the inner membrane of the mitochondrion because it binds more strongly than oxygen to the iron3+ in Cytochrome c oxidase3, preventing this cytochrome from combining electrons with oxygen. Contrary to popular belief, cyanide does not bind well to ferrous hemoproteins, such as hemoglobin, the mechanism which makes carbon monoxide toxic. One of the therapies for cyanide poisoning is to convert part of the hemoglobin of the blood from ferrous hemoglobin to ferric; this creates a pool of binding potential that can divert cyanide from the cytochromes it poisons. This is done with the compound 4-Dimethylaminophenyl, or with sodium nitrite. The standard cyanide antidote kit uses a small inhaled dose of amyl nitrite followed by intravenous sodium nitrite. This converts a portion of the hemoglobin's iron from ferrous iron to ferric iron, converting the hemoglobin into methemoglobin. Cyanide is more strongly drawn to methemoglobin than to the cytochrome oxidase of the cells, effectively pulling the cyanide off the cells and onto the methemoglobin. Once bound with the cyanide, the methemoglobin becomes cyanmethemoglobin. The next part of the cyanide antidote kit is sodium thiosulfate, which is administered intravenously. The sodium thiosulfate and cyanmethemoglobin becomes thiocyanate, releasing the hemoglobin, and the thiocyanate is excreted by the kidneys. ==Use as a poison== The cyanide ion, if used as poison, is generally delivered in the form of gaseous hydrogen cyanide or in the form of potassium cyanide (KCN) or sodium cyanide (NaCN). Zyklon B, the poison gas used in Nazi Germany gas chambers during the Holocaust, works by delivering hydrogen cyanide gas. Cyanide is also the compound used in United States death penalty chambers. Cyanide salts are sometimes used as fast acting "suicide pills". When they reach the stomach acids, cyanide ions are released; therefore they work faster on an empty stomach. Famous cyanide salt suicides include: *Hermann Göring *Joseph Goebbels *Adolf Hitler (debatable, see article on Hitler's death) *Alan Turing *Martin Bormann (dubious) *Heinrich Himmler *Erwin Rommel *Odilo Globocnik *Peoples Temple Jonestown mass suicide Poisoning by cyanide also figures prominently in crime fiction, for example Agatha Christie's ''Sparkling Cyanide'' (also titled ''Remembered Death''); cyanide is the instrument of one murder in ''The Big Sleep'' by Raymond Chandler. See also: Victims of poisoning Cyanides were stockpiled in both the Soviet Union and the United States chemical weapons arsenals in the 1950s and 1960s. During the Cold War, the Soviet Union was thought to be planning to use hydrogen cyanide as a "blitzkrieg" weapon to clear a path through the opposing front line, knowing that the harmful gas itself would evaporate and allow unprotected access to the captured zone. Some spy agents also carried glasses with cyanide in the frames. If they were caught by the enemy, they could casually chew the frame, releasing the cyanide, and die before being tortured or getting information extracted from them. The "cyanide glasses" can be found in the Washington D.C Spy Museum. == Mining == Cyanide salts are used in silver and gold mining, called the ''cyanide process''. The high grade ore is finely ground and mixed the cyanide solution (concentration of about two kilogram NaCN per tonne (1000 kilograms) or low grade ores are stacked into heaps and sprayed with cyanide solution (concentration of about one kilogram NaCN per tonne (1000 kilograms). The precious metal cations bind to the cyanide anions and form a ''soluble'' cyanide. The pregnant liquor is separated from the left-over dirt which is discarded to a tailing pond or spent (the recoverable gold having been removed) heap. The metal is recovered from the pregnant solution with zincdust that replace the gold in solution or by adsorption onto activated carbon. This process can result in environmental and health problems. Cyanide is highly reactive it decomposes rapidly in sunlight. It can mobilize some heavy metals like mercury (if mercury is present). Gold can also be associated with arsenopyrite, a pyrite (fools gold) where some iron gets replaced with arsenic. == Fishing == Cyanides are used to capture live fish near coral reefs for the aquarium and seafood market. This illegal fishing occurs mainly in the Philippines, Indonesia and the Caribbean to supply the 2 million marine aquarium owners in the world(Christie). In this method, a diver uses a large, needleless syringe to squirt a cyanide solution into areas where the fish are hiding, stunning them so that they can be easily gathered. The cyanide stuns the fish by affecting the uptake of Oxygen in their gills (Christie 2). Environmental organizations decry the practice, as do responsible aquarists and aquarium dealers. To prevent the trade of illegally caught aquarium fish, the Marine Aquarium Council have created a certification in which the tropical fish are caught legally with nets only. To insure authenticity, "MAC Certified marine organisms bear the 'MAC Certified' label on the tanks and boxes in which they are kept and shipped." *http://www.aquariumcouncil.org/subpage.asp?section=13 MAC Certification. The MAC certified fish are usually healthier and longer lived than cyanide caught fish, since their vital organs are not affeted by the deadly poison. Many fish caught in this fashion die either immediately or in shipping. Those that survive to find their way into pet stores often die from shock, or from massive digestive damage. The high concentrations of cyanide on reefs so harvested has also resulted in cases of cyanide poisioning among local fishermen and their families. The local villages in the Philippines and Indonesia despise the practice of cyanide fishing since they have realized the damaging affects of this poison on fish and reefs (Lowe). Cyanides Toxicology Chemical weapons lv:Cianīdi ==References== * Prof. Patrick Christie, University of Washington, Lecture, 4 May, 2005. * Prof. Patrick Christie, University of Washington, Lecture, 10 May, 2005. * Prof. Celia Lowe, University of Washington, Lecture, 6 May, 2005. == External Links == * [http://www.inchem.org/documents/cicads/cicads/cicad61.htm CICAD 61: Hydrogen cyanide and cyanides] * [http://www.inchem.org/documents/antidote/antidote/ant02.htm#SubSectionNumber:1.13.1 IPCS/CEC Evaluation of antidotes for poisoning by cyanides] * [http://www.atsdr.cdc.gov/MHMI/mmg8.html ATSDR medical management guidelines for cyanide poisoning (US)] * [http://www.hse.gov.uk/pubns/misc076.htm HSE recommendations for first aid treatment of cyanide poisoning (UK)] * [http://agmed.sante.gouv.fr/htm/10/piratox/piratox4.pdf Fiche piratox de prise en charge thérapeutique (France)] (''in French'') * [http://www.aquariumcouncil.org/default.asp Marine Aquarium Council Home Page]
Cyanide
I'm going to put this in talk so people can understand this clearly. I worked on heme proteins (and for that matter cyanide) well over ten years in graduate school and through a couple postdocs. Cyanide is a deadly compound because of its effects on ferric heme proteins. It doesn't bind especially well to ferrous heme proteins (that's carbon monoxide that does so). Cutting off cytochrome c oxidase, which cyanide does very well, will shut off aerobic metabolism, and because of the rise in concentration of metabolic intermediates, eventually shut down all anaerobic metabolism as well. Hemoglobin is a ferrous heme protein. One therapy for cyanide poisoning is to convert part of the hemoglobin in the blood to the ferric form, to provide a pool for internal cyanide and dilute the poison. That therapy would be useless if cyanide preferentially bound to the ferrous form of hemoproteins.User:dwmyers ---- I'm not really stalking you, Bryan. Two queries. (1) I didn't really understand the vitamin B13 sentence-can this be clarified. the second (2) I thought, possibly incorrectly, that almond oil was extrcated from sweet almonds? User:Jimfbleak 06:59 6 Jun 2003 (UTC) == How fast can cyanide kill? == Cyanide's toxicity is well-known. I'm under the impression that a large amount of the stuff is enough to deaden an adult person in seconds. It seems rather weird, though, so is it true? One imagines the suicide pills mentioned in the article would have to be pretty quick. -- User:Kizor 23:38, 9 Feb 2005 (UTC) *Seconds is a bit of an exageration for mortality. A few minutes seems the consensus, although loss of consciousness would be quicker and maybe as little as 30 seconds for a lethal dose of hydrogen cyanide gas. User:Physchim62 09:32, 3 Jun 2005 (UTC) == LD100 == What is the LD-100 (lethal dose at which point 100% of the subjects die) of (pure) cyanide? P.S. is [https://www1.fishersci.com/Coupon?gid=218110&cid=1336 this link] just CN? How can one have just CN? I thought CN was an ion... *LD100 values do not have much meaning as there is always variability in the reaction of individauls to different poisons: this is notoriously true of cyanides. Quoted LD50 values for potassium cyanide are 5–10 mg/kg for rodents. The IDLH (Immediate Danger to Life and Health) value is 25 mg/m3 (measured as cyanide, ''source'' [http://www.cdc.gov/niosh/npg/npgd0522.html NIOSH (US)]). User:Physchim62 10:54, 3 Jun 2005 (UTC) * The "Cyanide standard solution" that you cite will of course contain a counter-ion to ensure its electrical neutrality, doubtless either sodium or potassium. User:Physchim62 10:54, 3 Jun 2005 (UTC) == Antidote == The article does not mention about amyl nitrate being the antidote. Does anyone have any information regarding how soon after exposure to cyanide that amyl nitrate would be affective? Thank you *Amyl nitrite is not strictly an antidote. It is used as first aid, as it can be given my non-medically qualified people, while waiting for a doctor to arrive and administer an intravenous antidote. As amyl nitrite is inhaled, it would only be effective while the victim is still breathing, say during the first five minutes after acute poisoning (in any case, as soon as possible). Having said that, there is some debate as to whether amyl nitrate is effective at all (see the HSE link on the article page). User:Physchim62 09:29, 3 Jun 2005 (UTC)
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Cyanide
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