
Creatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). ==Physiology== It is mainly filtered by the kidney, though a small amount is actively secreted. Creatinine is not reabsorbed. If the filtering of the kidney is deficient, blood levels rise. This effect is used as an indicator of renal function. However, in cases of severe renal dysfunction, the creatinine clearance rate will be overestimated because the active secretion of creatinine will account for a larger fraction of the total creatinine cleared. Men tend to have higher levels of creatinine because they have more skeletal muscle than women. ==Diagnostic use== Measuring serum creatinine is a simple test and it is the most commonly used indicator of renal function. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. A better estimation of kidney function is given by the creatinine clearance test, which, however, is less convenient and unsuitable as a screening test because it requires the collection of urine over 24 hours. ==Interpretation== In the United States, creatinine is typically reported in mg/dL, while in Canada and Europe Mole (unit)/liter is used. 1 mg/dL of creatinine is 77.2 μmol/l. The reference range for women is considered 0.5 to 1.0 mg/dL (about 40-80 μmol/l), while the reference range for men is 0.9 to 1.4 mg/dL (70-110 μmol/l). While a baseline serum creatinine of 2.0 mg/dL (150 μmol/l) may indicate normal kidney function in a male body builder, a serum creatinine of 0.7 mg/dL (60 μmol/l) can indicate significant renal disease in a frail old woman. More important than absolute creatinine level is the trend of serum creatinine levels over time. A rising creatinine indicates kidney damage, while a declining creatinine level indicates improving kidney function. Proteins Chemical pathology
On the lines that follow in this article. Are the units supposed to be mg/dL instead of md/dL? While a baseline serum creatinine of 2.0 md/dL may indicate normal kidney function in a male body builder, a serum creatinine of 0.7 md/dL can indicate significant renal disease in a frail old woman" :They are. Just a typo on my part. I've fixed it. User:Richardsur 23:36, 23 Aug 2004 (UTC) Anybody know if μmol/L is really ''the'' SI unit of creatinine? I thought the differences were more based on region than anything else since mg/dL also uses SI/metric units. User:Richardsur 23:49, 23 Aug 2004 (UTC) According to the JAMA instruction to authors the SI units for creatinine are µmol/L. To convert use the following: Creatinine 1 mg/dL = 88.4 µmol/L dmborses@comcast.net
See other meanings of words starting from letter:
Words begining with Creatinine:
Creatinine
Creatinine
Creatinine_clearance
Creatinine_clearance_test
Creatinine
Creatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). ==Physiology== It is mainly filtered by the kidney, though a small amount is actively secreted. Creatinine is not reabsorbed. If the filtering of the kidney is deficient, blood levels rise. This effect is used as an indicator of renal function. However, in cases of severe renal dysfunction, the creatinine clearance rate will be overestimated because the active secretion of creatinine will account for a larger fraction of the total creatinine cleared. Men tend to have higher levels of creatinine because they have more skeletal muscle than women. ==Diagnostic use== Measuring serum creatinine is a simple test and it is the most commonly used indicator of renal function. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. A better estimation of kidney function is given by the creatinine clearance test, which, however, is less convenient and unsuitable as a screening test because it requires the collection of urine over 24 hours. ==Interpretation== In the United States, creatinine is typically reported in mg/dL, while in Canada and Europe Mole (unit)/liter is used. 1 mg/dL of creatinine is 77.2 μmol/l. The reference range for women is considered 0.5 to 1.0 mg/dL (about 40-80 μmol/l), while the reference range for men is 0.9 to 1.4 mg/dL (70-110 μmol/l). While a baseline serum creatinine of 2.0 mg/dL (150 μmol/l) may indicate normal kidney function in a male body builder, a serum creatinine of 0.7 mg/dL (60 μmol/l) can indicate significant renal disease in a frail old woman. More important than absolute creatinine level is the trend of serum creatinine levels over time. A rising creatinine indicates kidney damage, while a declining creatinine level indicates improving kidney function. Proteins Chemical pathology
Creatinine
On the lines that follow in this article. Are the units supposed to be mg/dL instead of md/dL? While a baseline serum creatinine of 2.0 md/dL may indicate normal kidney function in a male body builder, a serum creatinine of 0.7 md/dL can indicate significant renal disease in a frail old woman" :They are. Just a typo on my part. I've fixed it. User:Richardsur 23:36, 23 Aug 2004 (UTC) Anybody know if μmol/L is really ''the'' SI unit of creatinine? I thought the differences were more based on region than anything else since mg/dL also uses SI/metric units. User:Richardsur 23:49, 23 Aug 2004 (UTC) According to the JAMA instruction to authors the SI units for creatinine are µmol/L. To convert use the following: Creatinine 1 mg/dL = 88.4 µmol/L dmborses@comcast.net
See other meanings of words starting from letter:
C
CA | CB | CD | CE | CF | CG | CH | CI | CJ | CK | CL | CM | CN | CO | CP | CR | CS | CT | CU | CW | CX | CY | CZ |Words begining with Creatinine:
Creatinine
Creatinine
Creatinine_clearance
Creatinine_clearance_test
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