Amoxicillin

{| border="1" cellpadding="2" cellspacing="0" width="275px" align="right" |bgcolor="#ffffff" align="center" colspan="2"|
''Amoxicillin'' |- |bgcolor="#ffffff" align="center" colspan="2"| ''(2S,5R,6R)-6-[(R)-2-amino-2-(4-hydroxyphenyl)
acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
[3.2.0] heptane-2-carboxylic acid'' |- |bgcolor="#efefef"|Empirical formula |bgcolor="#dfefff"|C₁₆H₁₉N₃O₅S |- |bgcolor="#efefef"|Molecular weight |bgcolor="#dfefff"|365.4 |- |bgcolor="#efefef"|half life |bgcolor="#dfefff"|61.3 minutes |- |bgcolor="#efefef"|Excretion |bgcolor="#dfefff"|renal |- |bgcolor="#efefef"|Pregnancy category (pharmaceutical) |bgcolor="#dfefff"|A (Australia) |} Amoxicillin (International Nonproprietary Name) or amoxycillin (former British Approved Name) is a moderate-spectrum beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by beta-lactamase-producing bacteria, and so is often given with clavulanic acid (see below). It is currently marketed by GlaxoSmithKline under the trade name Amoxil®. ==Mode of action== Amoxicillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. ''Main article: beta-lactam antibiotic'' ==Microbiology== Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. Some examples of susceptible and resistant organisms, from the Amoxil� Approved Product Information (GSK, 2003), are listed below. ===Susceptible Gram-positive organisms=== ''Streptococcus'' spp., ''Diplococcus pneumoniae'', non beta-lactamase-producing ''Staphylococcus'' spp., and ''Streptococcus faecalis.'' ===Susceptible Gram-negative organisms=== ''Haemophilus influenzae'', ''Neisseria gonorrhoeae'', ''Neisseria meningitidis'', ''Escherichia coli'', ''Proteus mirabilis'' and ''Salmonella spp.'' ===Resistant organisms=== Penicillinase producing organisms, particularly penicillinase producing ''Staphylococcus'' spp. Penicillinase-producing ''N. gonorrhoeae'' and ''H. influenzae'' are also resistant All strains of ''Pseudomonas'' spp., ''Klebsiella'' spp., ''Enterobacter'' spp., indole-positive ''Proteus'' spp., ''Serratia'' marcescens, and ''Citrobacter'' spp. are resistant. The incidence of β-lactamase-producing resistant organisms, including ''E. coli'', appears to be increasing. == Amoxicillin and Clavulanic acid == Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production. This formulation is referred to as co-amoxiclav (British Approved Name), but more commonly by proprietary names such as Augmentin� and Clamoxyl�. ''Main article: co-amoxiclav'' == Proprietary Preparations == The patent for amoxicillin has expired. Thus amoxicillin is marketed under many trade names including: Actimoxi�, Amoxibiotic�, Amoxicilina�, Pamoxicillin�, Lamoxy�, Polymox�, Trimox�, Tolodina� and Zimox�. == References == * GlaxoSmithKline Australia Pty Ltd (2003). ''Amoxil� Approved Product Information.'' Boronia: GlaxoSmithKline. * Neal, MJ (2002). ''Medical Pharmacology at a Glance'' (4 ed.). Oxford: Blackwell Science. ISBN 0-632-05244-9 Beta-lactam antibiotics

Amoxicillin

I think this is not good practice to list or create articles about brand names (proprietary names). They come and go. Besides in different countries the same drug by the same manufacturer is sold under different brand names.
There are exceptions of course we definitely should have articles about : :Viagra,:Valium,:Prozac and possibly :Rophypnol (date-rape drug ?). Can we ask the administrators to issue the official policy on brand names of pharmaceuticals ? ---- There is not yet an official policy, but personally I don't have a problem with it. If it's a subject some people want to know about, we do our readers a disservice not to cover it just because of some misplaced concern about "commercialism". Let's face it; people won't search for "Diazepam"; they'll search for "Valium", and expect an article on it. Of course, that article should simply say that "Valium" is a trademarked brand name for Diazepam, and then desribe what Diazepam is and what it does. I think all should be treated similarly: mention the brand name and the generic name, and use the generic name in most of the text. --LDC ---- I think we can create redirects from lesser known brand names to generic names pages but we should stick to generic (or better INN - international names) throughout the text of articles possibly giving brand names at the top or in brackets.

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Words begining with Amoxicillin:

Amoxicillin
Amoxicillin
Amoxicillin_Trihydrate