Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleep and inattention in elderly patients. It is also used off-label by individuals wishing to avoid Fatigue (physical), such as night workers or others who need to stay awake and alert for long periods of time. Adrafinil is a prodrug; it is primarily metabolized ''in vivo'' to modafinil (''Provigil''®), resulting in nearly identical pharmacology effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45-60 minutes when taken orally on an empty stomach. Adrafinil, also known by the codename CRL 40028, has as its chemical name 2-(Diphenylmethyl) sulfinyl acetohydroxamic acid. Its molecular formula is C15H15NO3S. The drug's molecular weight is 289.4 kilodaltons. Adrafinil was discovered in the late 1970s by scientists working with the French pharmaceutical company Group Lafon. The drug was first offered as an experimental treatment for narcolepsy in France in 1986. Later on Lafon scientists developed modafinil as a stand-alone drug because the latter drug was understood to be a more highly selective alpha-1 adrenergic and also featured less in the way of side effects such as stomach pain, skin irritations, inner tension and an increase in liver enzyme levels. Adrafinil does not currently have Food and Drug Administration approval in the United States, although it is used in France and elsewhere in Europe. The drug is marketed by the American pharmaceutical company Cephalon, which acquired Group Lafon in 2001, under the brand name ''Olmifon''. Stimulants Nootropics == External Links == * [http://www.nevapress.com/cnsdr/full/5/3/193.pdf ''Adrafinil: A Novel Vigilance Promoting Agent'' by Norton W. Milgram, Heather Callahan, and Christina Siwak of the University of Toronto at Scarborough, CNS Drug Reviews, Vol. 5, No. 3, pp. 193-212]
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Adrafinil
Adrafinil
Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleep and inattention in elderly patients. It is also used off-label by individuals wishing to avoid Fatigue (physical), such as night workers or others who need to stay awake and alert for long periods of time. Adrafinil is a prodrug; it is primarily metabolized ''in vivo'' to modafinil (''Provigil''®), resulting in nearly identical pharmacology effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45-60 minutes when taken orally on an empty stomach. Adrafinil, also known by the codename CRL 40028, has as its chemical name 2-(Diphenylmethyl) sulfinyl acetohydroxamic acid. Its molecular formula is C15H15NO3S. The drug's molecular weight is 289.4 kilodaltons. Adrafinil was discovered in the late 1970s by scientists working with the French pharmaceutical company Group Lafon. The drug was first offered as an experimental treatment for narcolepsy in France in 1986. Later on Lafon scientists developed modafinil as a stand-alone drug because the latter drug was understood to be a more highly selective alpha-1 adrenergic and also featured less in the way of side effects such as stomach pain, skin irritations, inner tension and an increase in liver enzyme levels. Adrafinil does not currently have Food and Drug Administration approval in the United States, although it is used in France and elsewhere in Europe. The drug is marketed by the American pharmaceutical company Cephalon, which acquired Group Lafon in 2001, under the brand name ''Olmifon''. Stimulants Nootropics == External Links == * [http://www.nevapress.com/cnsdr/full/5/3/193.pdf ''Adrafinil: A Novel Vigilance Promoting Agent'' by Norton W. Milgram, Heather Callahan, and Christina Siwak of the University of Toronto at Scarborough, CNS Drug Reviews, Vol. 5, No. 3, pp. 193-212]
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